Related Papers
Porto Biomedical Journal
The influence of gut microbiota in cardiovascular diseases—a brief review
2021 •
Cátia Almeida
Frontiers in Cellular and Infection Microbiology
The Gut Microbiota (Microbiome) in Cardiovascular Disease and Its Therapeutic Regulation
Popy Rani Sutradhar 191-29-1466
In the last two decades, considerable interest has been shown in understanding the development of the gut microbiota and its internal and external effects on the intestine, as well as the risk factors for cardiovascular diseases (CVDs) such as metabolic syndrome. The intestinal microbiota plays a pivotal role in human health and disease. Recent studies revealed that the gut microbiota can affect the host body. CVDs are a leading cause of morbidity and mortality, and patients favor death over chronic kidney disease. For the function of gut microbiota in the host, molecules have to penetrate the intestinal epithelium or the surface cells of the host. Gut microbiota can utilize trimethylamine, N-oxide, short-chain fatty acids, and primary and secondary bile acid pathways. By affecting these living cells, the gut microbiota can cause heart failure, atherosclerosis, hypertension, myocardial fibrosis, myocardial infarction, and coronary artery disease. Previous studies of the gut microbio...
Journal of Mind and Medical Sciences
Intestinal microbiota – a possible contributor to cardiovascular diseases?
2020 •
Roua Anamaria Iorga
Cardiovascular Research
Mechanisms, therapeutic implications, and methodological challenges of gut microbiota and cardiovascular diseases: a position paper by the ESC Working Group on Coronary Pathophysiology and Microcirculation
marija vavlukis
The human gut microbiota is the microbial ecosystem in the small and large intestines of humans. It has been naturally preserved and evolved to play an important role in the function of the gastrointestinal tract and the physiology of its host, protecting from pathogen colonization, and participating in vitamin synthesis, the functions of the immune system, as well as glucose homeostasis and lipid metabolism, among others. Mounting evidence from animal and human studies indicates that the composition and metabolic profiles of the gut microbiota are linked to the pathogenesis of cardiovascular disease, particularly arterial hypertension, atherosclerosis, and heart failure. In this review article, we provide an overview of the function of the human gut microbiota, summarize, and critically address the evidence linking compositional and functional alterations of the gut microbiota with atherosclerosis and coronary artery disease and discuss the potential of strategies for therapeutical...
Nutrients
Bridging the Gap between Gut Microbial Dysbiosis and Cardiovascular Diseases
2017 •
Ayesha rizwan
The human gut is heavily colonized by a community of microbiota, primarily bacteria, that exists in a symbiotic relationship with the host and plays a critical role in maintaining host homeostasis. The consumption of a high-fat (HF) diet has been shown to induce gut dysbiosis and reduce intestinal integrity. Recent studies have revealed that dysbiosis contributes to the progression of cardiovascular diseases (CVDs) by promoting two major CVD risk factors-atherosclerosis and hypertension. Imbalances in host-microbial interaction impair homeostatic mechanisms that regulate health and can activate multiple pathways leading to CVD risk factor progression. Dysbiosis has been implicated in the development of atherosclerosis through metabolism-independent and metabolite-dependent pathways. This review will illustrate how these pathways contribute to the various stages of atherosclerotic plaque progression. In addition, dysbiosis can promote hypertension through vascular fibrosis and an alt...
THE INFLUENCE OF THE INTESTINAL MICROBIOTA ON CARDIOVASCULAR HEALTH: AN INTEGRATIVE REVIEW (Atena Editora)
THE INFLUENCE OF THE INTESTINAL MICROBIOTA ON CARDIOVASCULAR HEALTH: AN INTEGRATIVE REVIEW (Atena Editora)
2023 •
Atena Editora
Introduction: The gut microbiota plays a key role in human health, influencing various physiological processes in cardiovascular health. Objective: To analyze the scientific research that investigates the relationship between the intestinal microbiota and cardiovascular health, in particular the existing evidence on how the composition of the intestinal microbiota affects the development of cardiovascular diseases. Methodology: Articles relevant to the work were selected, including clinical trial, meta-analysis, literature review and systematic literature review, through the platform's data base PubMed, using the keywords "Gut microbiota" and "Heart disease". Results: The studies investigated different aspects of the relationship between intestinal microbiota and cardiovascular health, including the influence of intestinal dysbiosis, microbial diversity, metabolites produced by the microbiota and the immunological mechanisms involved. The results suggest that alterations in the composition of the intestinal microbiota may be associated with an increased risk of cardiovascular diseases, including atherosclerosis, hypertension and ischemic heart disease. Conclusion: Based on the integrative literature review, there is growing evidence that the gut microbiota plays a relevant role in cardiovascular health. Understanding the mechanisms involved in this relationship can provide important insights for the development of new therapeutic strategies and interventions based on the modulation of the intestinal microbiota. However, further studies are needed to fully elucidate the underlying mechanisms and establish effective interventions to improve cardiovascular health through manipulation of the gut microbiota.
Current pharmaceutical design
Gut microbiota: a new marker of cardiovascular disease
2017 •
Francisco Pérez-jiménez
Cardiovascular disease (CVD) continues to be the major cause of death in the developed countries. Moreover, the cardiovascular risk factors leading towards the development of CVD, mainly type 2 diabetes and obesity, are on the rise. The current preventive and therapeutic management, centred on the control of traditional risk factors, is clearly not enough to stop this pandemic. Therefore, the search for new biomarkers in CVD is a priority in most clinical research programs. Currently, interest in gut microbiota has peaked due to its association with cardiovascular and non-cardiovascular diseases. The present review considers the current situation regarding the influence of gut microbiota on CVD and particularly, its influence on the main traditional risk factors that lead to CVD, such as lipids, diabetes, hypertension and obesity.
Cureus
The Gut Microbiome and Cardiovascular Disease
2021 •
Harvey Mayrovitz
Canadian Journal of Microbiology
Understanding connections and roles of gut microbiome in cardiovascular diseases
2021 •
BALAMURUGAN RAMADASS
The gut microbiome encompasses trillions of residing microbes, mainly bacteria, which play a crucial role in maintaining the physiological and metabolic health of the host. The gut microbiome has been associated with several diseases, including cardiovascular disease (CVD). A growing body of evidence suggests that an altered gut environment and gut-microbiome-derived metabolites are associated with CVD events. The gut microbiome communicates with host physiology through different mechanisms, including trimethylamine N-oxide generation, primary and secondary bile acid metabolism pathways, and short-chain fatty acids production. The main focus of this review is to understand the association of the gut microbiome with CVD and its implications on the interactions between the gut microbiome and the host. Manipulation of the gut microbiome through specific dietary intervention is a simple approach to identifying novel targets for therapy or better dietary recommendations, and new preventi...
Advanced Gut & Microbiome Research
Dysbiosis—An Etiological Factor for Cardiovascular Diseases and the Therapeutic Benefits of Gut Microflora
ashmeen kaur
The human gut is colonized by a variety of microorganisms especially bacteria. There are multiple evidences that gut microflora dysbiosis is a novel risk factor for development of various intestine-related diseases such as irritable bowel syndrome and inflammatory bowel disease as well as nonintestinal diseases including obesity, type II diabetes, and cardiovascular diseases. A mutual relationship among the host’s immune system and the metabolites produced by the gut microflora, including trimethylamine N-oxide (TMAO), short-chain fatty acids (SCFAs), and bile acids, is present. Alterations in the host-microbial interaction lead to impaired homeostasis and thus contribute towards the activation of several pathways that causes progression of cardiovascular diseases. This review summarizes the role of gut microflora dysbiosis in the development and progression of atherosclerosis, coronary artery disease, and hypertension. Dysbiosis has been implicated in the pathogenesis of atheroscle...
